| Sluice Gap | on the Swain County, N.C.-Sevier County, Tenn., line between Mount Kephart and The Sawteeth. |
| Sly | community in W Ashe County. |
| Small | community in S central Beaufort County. |
| Smallwood Island | a silty clay-loam island approx. 1¼ mi. long in Roanoke River, W Northampton County. |
| Smart Branch | rises in S Macon County and flows SW into Middle Creek. |
| Smathers View Mountain | extends E from Thompson Knob, which see, to Peggy Peak in SW Buncombe County. |
| Smethport | community in central Ashe County. Named for the town in Pennsylvania from which a local tanning extract plant had moved. |
| Smileys Falls | S Harnett County in Cape Fear River at the mouth of Upper Little River. A succession of ledges of rock there drops the water from 6 to 18 inches in most cases, but there is one fall of 4 ft. and another of 5 ft. Mentioned in Fulton's survey of North Carolina rivers in 1819. |
| Smith | community in N Forsyth County served by post office, 1883-1925. |
| Smith Branch | rises in S central Cabarrus County and flows NE into Coddle Creek. |