| Slickrock Mountain | W central Yancey County between Phipps and Baker Creeks. |
| Slide Branch | rises in NW Haywood County and flows N into Big Creek. |
| Sliding Knob Creek | rises in SW Madison County and flows W into Spring Creek. |
| Sligo | community in N Currituck County on the W side of Tull Creek. Served by post office, 1854-1910. Named by a Methodist circuit rider from Sligo, Ireland, who visited the area in 1783. Also known as Cowell's Bridge. |
| Slim Creek | rises in N McDowell County on the W slope of Betsy Ridge and flows S into Little Buck Creek. |
| Slipoff Branch | rises in E Swain County and flows NE into Connelly Creek. |
| Slipoff Knob | E Swain County between the head of Connelly Creek and the head of Slipoff Branch. |
| Slippery Hill Ridge | W Avery County. |
| Sloan | community in SE Duplin County served by post office, 1884-1920. Alt. 50. |
| Sloan | or See Stony Point. |