| Sixpound Creek | rises in N central Warren County and flows N then NE into Lake Gaston. Appears on the Moseley map, 1733. |
| Sixpound Township | N Warren County. |
| Skalley Branch | rises in N Avery County and flows W into Elk River. |
| Skalley Knob | N Avery County. |
| Skeenah Creek | is formed in S Macon County by the junction of North Fork [Skeenah Creek] and South Fork [Skeenah Creek] and flows E into Little Tennessee River. The name is said to be an Indian word meaning "the abode of satan." |
| Skeenah Gap | S Macon County between Black Mountain Branch and Jones Creek. |
| Skewarky | See Williamston. |
| Skibo | or Skibow (Sky-bow), community in central Cumberland County. Alt. 221. |
| Skidder Branch | rises in NE Swain County and flows SE into Straight Fork. |
| Skiffley Creek | rises in N Haywood County and flows SE into Pigeon River. |