| Big Branch | rises near Potato Knob in NE Buncombe County and flows S into Right Fork. |
| Big Branch | rises in S Columbus County and flows SW into Grissett Swamp. |
| Big Branch | rises in NW Cumberland County and flows SE into Beaver Creek. |
| Big Branch | rises in SE Alexander County and flows SE into Elk Shoal Creek. |
| Big Branch | rises in W Avery County and flows NE into Horse Creek. |
| Big Branch | rises in W Avery County and flows SW into Roaring Creek. |
| Big Buckeye Cove | SE Haywood County on the head of East Fork Pigeon River. |
| Big Buffalo Creek | rises in central Lee County and flows NW into Deep River. |
| Big Bugaboo Creek | rises in NE Wilkes County and flows S into Yadkin River. |
| Big Butt | on the Madison County, N.C.-Greene County, Tenn., line. Alt. 4,836. |